Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2167814 | 0.80 | ASAH1 (0.63) | ALDH1A1ASAH1ACER2 | |
| SCHEMBL28229063 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL17702817 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL12265956 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL12313665 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL8001841 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL8209874 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL8001842 | 0.79 | LMNA (0.56) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| SCHEMBL9126861 | 0.79 | MMP8 (0.54) | KDM4ELMNAADRA2CADRA2AHIF1A | |
| Propionic Acid SCHEMBL1081848 | 0.78 | KDM4E (0.50) | KDM4ELMNAADRA2CADRA2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196192-B2 | 28-epirapalogs | ARIAD GENE THERAPEUTICS, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| CN-1293081-C | 28-epirapalogs | ARIAD GENE THERAPEUTICS INC (US) | 2007-01-03 | — | — | CN | disclosed |
| US-7067526-B1 | 28-epirapalogs | ARIAD GENE THERAPEUTICS, INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-20060025356-A1 | 28-epirapalogs | ARIAD PHARMACEUTICALS, INC. | 2006-02-02 | — | — | US | disclosed |
| EP-1212331-B1 | 28-EPIRAPALOGS | ARIAD GENE THERAPEUTICS INC (US) | 2004-04-21 | — | — | EP | disclosed |
| CN-1371378-A | 28-epi rapamycin analogs | ARIAD GENE THERAPEUTICS INC (US) | 2002-09-25 | — | — | CN | disclosed |
| EP-1212331-A1 | 28-EPIRAPALOGS | ARIAD GENE THERAPEUTICS, INC. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014387-A1 | 28-EPIRAPALOGS | ARIAD GENE THERAPEUTICS, INC. (US) | 2001-03-01 | — | — | WO | disclosed |
| US-5426201-A | Reacting an alkali or alkaline earth metal enolate with manganous compounds | SOCIETE NATIONALE ELF AQUITAINE (FR) | 1995-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025356-A1 | 28-epirapalogs | RPL27, TOP2A, TOP2B | KDM4E 3526/4885LMNA 2944/4885ADRA2C 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.