Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4723016 | 0.90 | KDM4E (0.52) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5076869 | 0.80 | SMN1; SMN2 (0.53) | KDM4EMEN1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL154368 | 0.79 | HSD17B10 (0.68) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5657613 | 0.78 | ABL1 (0.51) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29002583 | 0.78 | PYCR1 (0.46) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16293655 | 0.78 | KDM4E (0.52) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL6424557 | 0.77 | LDHA (0.53) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3659915 | 0.76 | HSD17B10 (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2HSD17B10 | |
| SCHEMBL6307470 | 0.76 | CYP3A4 (0.61) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL137400 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |