Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2734577 | 0.90 | ABL1 (0.59) | ABL1RIN1HDAC1HDAC6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6424557 | 0.89 | LDHA (0.53) | ABL1RIN1ALDH1A1GAALMNA | |
| SCHEMBL138449 | 0.79 | GAA (0.68) | ABL1RIN1HDAC1HDAC6ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5658221 | 0.78 | KDM4E (0.48) | ALDH1A1GAALMNAMEN1KDM4E | |
| SCHEMBL1033641 | 0.77 | LMNA (0.61) | ABL1RIN1ALDH1A1GAALMNA | |
| SCHEMBL29602721 | 0.77 | LMNA (0.61) | ABL1RIN1ALDH1A1GAALMNA | |
| SCHEMBL17653947 | 0.77 | ALDH1A1 (0.45) | ABL1RIN1ALDH1A1GAALMNA | |
| Trifluoroacetic Acid SCHEMBL5655817 | 0.77 | HTT (0.51) | ALDH1A1 | |
| SCHEMBL2853330 | 0.76 | HDAC1 (0.58) | ABL1RIN1HDAC1HDAC6ALDH1A1 | |
| SCHEMBL21916942 | 0.76 | HDAC1 (0.54) | ABL1RIN1HDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |