Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CDC25B | P30305 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27619014 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HSD17B10KDM4ENCOA1NCOA3 | |
| SCHEMBL28788244 | 0.80 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1HSD17B10PSMD14KDM4E | |
| SCHEMBL30232753 | 0.78 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL126054 | 0.78 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1HSD17B10CFTRKDM4E | |
| SCHEMBL5656450 | 0.78 | TDP1 (0.51) | L3MBTL1ALDH1A1KDM4ENCOA1NCOA3 | |
| SCHEMBL22948056 | 0.76 | ALDH1A1 (0.42) | L3MBTL1ALDH1A1HSD17B10CFTRPSMD14 | |
| SCHEMBL31224994 | 0.76 | ALDH1A1 (0.42) | L3MBTL1ALDH1A1HSD17B10CFTRPSMD14 | |
| SCHEMBL7631322 | 0.76 | CNR2 (0.52) | L3MBTL1PSMD14KDM4ESTAT3HIF1A | |
| SCHEMBL30301713 | 0.76 | CNR2 (0.52) | L3MBTL1PSMD14KDM4ESTAT3HIF1A | |
| SCHEMBL8416022 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HSD17B10CFTRPSMD14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7285563-B2 | Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2007-10-23 | — | — | US | disclosed |
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | MERCK SHARP & DOHME LTD. (GB) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107388-A1 | Heteroaromatic urea derivatives as vr-1receptor modulators for treating pain | ARRB1, OPRL1, CNR1 | L3MBTL1 4408/4885ALDH1A1 1267/4885HSD17B10 3400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.