Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CXCR1 | P25024 | 10/20 | 0.52 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5658828 | 0.84 | CXCR1 (0.51) | NPC1RAB9ASMN1; SMN2CXCR1CXCR2 | |
| SCHEMBL5661096 | 0.84 | CXCR2 (0.67) | NPC1RAB9ASMN1; SMN2MAPTCXCR1 | |
| SCHEMBL5658045 | 0.82 | CXCR2 (0.59) | NPC1RAB9AMEN1KMT2ACXCR1 | |
| SCHEMBL5658349 | 0.81 | CXCR2 (0.73) | NPC1RAB9ACXCR1CXCR2ALDH1A1 | |
| SCHEMBL5656795 | 0.81 | CXCR2 (0.76) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL5656391 | 0.80 | CXCR1 (0.75) | MAPTMEN1KMT2ACXCR1CXCR2 | |
| SCHEMBL5659069 | 0.80 | CXCR2 (0.59) | NPC1RAB9AMAPTCXCR1CXCR2 | |
| SCHEMBL5660773 | 0.80 | CXCR2 (0.52) | KMT2ACXCR1CXCR2ALDH1A1RECQL | |
| SCHEMBL5660902 | 0.77 | CXCR1 (0.56) | NPC1RAB9ASMN1; SMN2CXCR1CXCR2 | |
| SCHEMBL5662987 | 0.77 | CXCR2 (0.51) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |