Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 4/20 | 0.34 |
| ▸ | NOS1 | P29475 | 4/20 | 0.34 |
| ▸ | NOS2 | P35228 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP2 | P12104 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10064859 | 1.00 | HTR7 (0.38) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL10064857 | 1.00 | HTR7 (0.38) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL14647146 | 0.84 | TFPI2 (0.38) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL18939739 | 0.81 | HTR7 (0.49) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL565845 | 0.80 | GRM2 (0.42) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL10064856 | 0.80 | GRM2 (0.42) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL10064858 | 0.80 | GRM2 (0.42) | HTR7HTR2AHTR2COPRM1OPRD1 | |
| SCHEMBL566179 | 0.80 | SMN1; SMN2 (0.36) | HTR7HTR2AHTR2CDRD2SLC6A4 | |
| SCHEMBL22439524 | 0.79 | HTR7 (0.48) | HTR7HTR2AHTR2CDRD2SLC6A4 | |
| SCHEMBL2264672 | 0.78 | NOS3 (0.48) | HTR7HTR2AHTR2COPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346505-B1 | INDOLE AND BENZOMORPHOLINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8697689-B2 | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors | Janssen Pharmaceuticals, Inc. (US) | 2014-04-15 | — | — | US | disclosed |
| CN-102186477-B | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors | ORTHO MCNEIL JANSSEN PHARM | 2013-07-17 | — | — | CN | disclosed |
| EP-2373649-B1 | INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | JANSSEN PHARMACEUTICALS INC (US) | 2013-01-23 | — | — | EP | disclosed |
| US-20120035167-A1 | INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Janssen Pharmaceuticals, Inc. | 2012-02-09 | — | — | US | disclosed |
| CN-102232074-A | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors | ORTHO MCNEIL JANSSEN PHARM | 2011-11-02 | — | — | CN | disclosed |
| CN-102186477-A | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors | ORTHO MCNEIL JANSSEN PHARM | 2011-09-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035167-A1 | INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM2, GRM5, GRIA2 | HTR7 82/4885HTR2A 29/4885HTR2C 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.