⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513825 | 0.75 | — | — | |
| SCHEMBL1017724 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL17595132 | 0.74 | GABRP (0.31) | — | |
| SCHEMBL2536922 | 0.69 | — | — | |
| SCHEMBL8247995 | 0.68 | GPR84 (0.31) | — | |
| Trifluoroacetic Acid SCHEMBL17595019 | 0.67 | — | — | |
| SCHEMBL6966349 | 0.66 | — | — | |
| SCHEMBL11667115 | 0.64 | — | — | |
| SCHEMBL19062334 | 0.63 | GRM4 (0.33) | — | |
| SCHEMBL13255050 | 0.62 | TSHR (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62205068-A | — | — | None | — | — | JP | disclosed |
| EP-2888248-A1 | SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | Boehringer Ingelheim International GmbH (DE) | 2015-07-01 | — | — | EP | disclosed |
| WO-2014029831-A1 | SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-27 | — | — | WO | disclosed |
| EP-1432815-A4 | QUINONE REDUCTASE 2 AND ALDEHYDE DEHYDROGENASE AS THERAPEUTIC TARGETS | UNIV DUKE (US) | 2006-02-22 | — | — | EP | disclosed |
| EP-1432815-A2 | QUINONE REDUCTASE 2 AND ALDEHYDE DEHYDROGENASE AS THERAPEUTIC TARGETS | Duke University (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003025128-A9 | QUINONE REDUCTASE 2 AND ALDEHYDE DEHYDROGENASE AS THERAPEUTIC TARGETS | UNIV DUKE (US) | 2004-04-29 | — | — | WO | disclosed |
| US-20030143645-A1 | Quinone reductase 2 and aldehyde dehydrogenase as therapeutic targets | VENTURE LENDING & LEASING IV, INC. | 2003-07-31 | — | — | US | disclosed |
| WO-2003025128-A2 | QUINONE REDUCTASE 2 AND ALDEHYDE DEHYDROGENASE AS THERAPEUTIC TARGETS | DUKE UNIVERSITY (US) | 2003-03-27 | — | — | WO | disclosed |
| EP-0661986-A4 | BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM. | UNIV FLORIDA (US) | 1997-04-23 | — | — | EP | disclosed |
| EP-0661986-A1 | BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM | UNIVERSITY OF FLORIDA (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994006450-A1 | BRAIN-ENHANCED DELIVERY OF NEUROACTIVE PEPTIDES BY SEQUENTIAL METABOLISM | UNIVERSTIY OF FLORIDA (US) | 1994-03-31 | — | — | WO | disclosed |
| JP-S62205068-A | PRODUCTION OF EPOXY COMPOUND | TABUSE IWAO | 1987-09-09 | — | — | JP | disclosed |