Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.76 |
| ▸ | CXCR1 | P25024 | 9/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5656674 | 0.88 | CXCR2 (0.74) | CXCR2CXCR1NPC1RAB9AATM | |
| SCHEMBL5657748 | 0.86 | CXCR2 (0.65) | CXCR2CXCR1MEN1KMT2ANPC1 | |
| SCHEMBL5846226 | 0.86 | CXCR2 (1.00) | CXCR2CXCR1 | |
| SCHEMBL5659975 | 0.79 | CXCR2 (0.73) | CXCR2CXCR1NPC1RAB9AP4HTM | |
| SCHEMBL14587553 | 0.78 | P4HTM (0.57) | CXCR2CXCR1MEN1KMT2ANPC1 | |
| SCHEMBL5658349 | 0.78 | CXCR2 (0.73) | CXCR2CXCR1NPC1RAB9AATM | |
| SCHEMBL5846271 | 0.76 | CXCR2 (1.00) | CXCR2CXCR1 | |
| SCHEMBL5659675 | 0.74 | SMN1; SMN2 (0.54) | CXCR2CXCR1MEN1KMT2ANPC1 | |
| SCHEMBL5846277 | 0.73 | CXCR1 (1.00) | CXCR2CXCR1NPC1RAB9AATM | |
| SCHEMBL13197192 | 0.73 | CXCR2 (0.77) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176310-B1 | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents | UCB SA (GB) | 2007-02-13 | — | — | US | disclosed |