Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCG | P05129 | 5/20 | 0.69 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.69 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.69 |
| ▸ | PRKCB | P05771 | 4/20 | 0.69 |
| ▸ | PRKCA | P17252 | 4/20 | 0.69 |
| ▸ | PRKCH | P24723 | 4/20 | 0.69 |
| ▸ | PRKCI | P41743 | 4/20 | 0.69 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.69 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.69 |
| ▸ | PRKACA | P17612 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.69 |
| ▸ | PRKACG | P22612 | 3/20 | 0.69 |
| ▸ | PRKACB | P22694 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968125 | 0.82 | PRKACA (1.00) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| SCHEMBL1272424 | 0.82 | PRKACA (1.00) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| SCHEMBL10983368 | 0.81 | PRKCG (0.73) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| SCHEMBL9541290 | 0.81 | PRKCG (0.86) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| Hydrochloric Acid SCHEMBL29993804 | 0.81 | LMNA (1.00) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| Hydrochloric Acid SCHEMBL30574273 | 0.81 | LMNA (1.00) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| Hydrochloric Acid SCHEMBL2383301 | 0.81 | LMNA (1.00) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| Hydrochloric Acid SCHEMBL1165673 | 0.81 | LMNA (1.00) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| SCHEMBL5665334 | 0.80 | PRKD3 (0.55) | PRKCGPRKCZPRKCDPRKD3PRKCB | |
| SCHEMBL5663814 | 0.80 | PRKACA (0.85) | PRKCGPRKCZPRKCDPRKD3PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094789-B2 | 5-substituted isoquinoline derivatives | ASAHI KASEI PHARMA CORPORATION (JP) | 2006-08-22 | — | — | US | disclosed |
| EP-1541559-A1 | 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE | Asahi Kasei Pharma Corporation (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20050020623-A1 | 5-Substituted isoquinoline derivatives | ASAHI KASEI PHARMA CORPORATION (JP) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020623-A1 | 5-Substituted isoquinoline derivatives | MYLK, MYLK2, MYL12A | PRKCG 139/4885PRKCZ 97/4885PRKCD 332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.