Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957869 | 0.89 | KMT2A (0.47) | LMNAALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL2162271 | 0.84 | LMNA (0.55) | LMNAALDH1A1ADRB1ADRB3L3MBTL1 | |
| SCHEMBL5719253 | 0.82 | LMNA (0.53) | LMNAALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL10399389 | 0.82 | RECQL (0.59) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL14461610 | 0.79 | LMNA (0.50) | LMNAALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL4285383 | 0.78 | TRPA1 (0.43) | FFAR1 | |
| SCHEMBL7567777 | 0.77 | LMNA (0.60) | LMNAPOLBADRB1ADRB3L3MBTL1 | |
| SCHEMBL8528333 | 0.77 | TDP1 (0.44) | LMNAALDH1A1POLBALOX5 | |
| SCHEMBL25251735 | 0.76 | PLA2G4B (0.56) | LMNAALDH1A1DRD2DRD3ADRB1 | |
| SCHEMBL6898511 | 0.75 | LMNA (0.63) | LMNAALDH1A1ADRB1ADRB3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101539-B2 | Use of LP82 to treat hematopoietic disorders | ELI LILLY AND COMPANY (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1511511-A4 | USE OF IL-19, IL-22 AND IL-24 TO TREAT HEMATOPOIETIC DISORDERS | LILLY CO ELI (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050054567-A1 | Use of il-19,il-22 and il-24 to treat hematopoietic disorders | ROWLINSON SCOTT WILLIAM (US) | 2005-03-10 | — | — | US | disclosed |
| EP-1511511-A2 | USE OF IL-19, IL-22 AND IL-24 TO TREAT HEMATOPOIETIC DISORDERS | ELI LILLY AND COMPANY (US) | 2005-03-09 | — | — | EP | disclosed |
| EP-1494717-A2 | USE OF RESISTIN TO TREAT HEMATOPOIETIC DISORDERS | ELI LILLY AND COMPANY (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20040092445-A1 | Use of LP82 to treat hematopoietic disorders | HEUER JOSEF GEORG (US) | 2004-05-13 | — | — | US | disclosed |
| EP-1390060-A2 | USE OF LP82 TO TREAT BODY WEIGHT DISORDERS | ELI LILLY AND COMPANY (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1383531-A2 | USE OF LP82 TO TREAT HEMATOPOIETIC DISORDERS | ELI LILLY AND COMPANY (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2003089569-A2 | USE OF IL-19, IL-22 AND IL-24 TO TREAT HEMATOPOIETIC DISORDERS | ELI LILLY AND COMPANY (US) | 2003-10-30 | — | — | WO | disclosed |
| WO-2003086320-A2 | USE OF RESISTIN TO TREAT HEMATOPOIETIC DISORDERS | ELI LILLY AND COMPANY (US) | 2003-10-23 | — | — | WO | disclosed |
| WO-2002070001-A2 | USE OF LP82 TO TREAT HEMATOPOIETIC DISORDERS | ELI LILLY AND COMPANY (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-2002058724-A2 | USE OF LP82 TO TREAT BODY WEIGHT DISORDERS | ELI LILLY AND COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |
| WO-2002002771-A2 | HUMAN SPARC-HOMOLOGOUS (HSPARC-H1) GENE AND METHODS AND USES THEREOF | ELI LILLY AND COMPANY (US) | 2002-01-10 | — | — | WO | disclosed |
| WO-2001066738-A2 | NUCLEIC ACIDS, ENCODING HUMAN CRSP1 AND USES THEREOF | ELI LILLY AND COMPANY (US) | 2001-09-13 | — | — | WO | disclosed |