Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 15/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664181 | 0.89 | PTAFR (0.57) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL5664306 | 0.85 | PTAFR (0.43) | PTAFROPRK1PDE4D | |
| SCHEMBL5665941 | 0.85 | PTAFR (0.42) | PTAFROPRK1PDE4DTDP1 | |
| SCHEMBL5663627 | 0.85 | OPRK1 (0.48) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL5664536 | 0.84 | OPRK1 (0.45) | PTAFROPRK1PDE4D | |
| SCHEMBL5664178 | 0.82 | PTAFR (0.48) | PTAFROPRK1PDE4D | |
| SCHEMBL5664049 | 0.82 | PTAFR (0.43) | PTAFROPRK1PDE4D | |
| SCHEMBL5666605 | 0.82 | PTAFR (0.46) | PTAFROPRK1PDE4D | |
| SCHEMBL5664204 | 0.81 | PTAFR (0.45) | PTAFROPRK1PDE4D | |
| SCHEMBL5666304 | 0.81 | PTAFR (0.42) | PTAFROPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7015213-B1 | Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2006-03-21 | — | — | US | claimed |
| US-7015213-B1 | Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2006-03-21 | — | — | US | disclosed |