Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 16/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664142 | 0.89 | PTAFR (0.46) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL5663627 | 0.88 | OPRK1 (0.48) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL5664536 | 0.87 | OPRK1 (0.45) | PTAFROPRK1PDE4D | |
| SCHEMBL24997553 | 0.86 | PTAFR (0.60) | PTAFROPRK1PDE4DGABRA1GABRG2 | |
| SCHEMBL5666201 | 0.86 | GABRA1 (0.43) | PTAFROPRK1PDE4DGABRA1GABRA5 | |
| SCHEMBL5664049 | 0.86 | PTAFR (0.43) | PTAFROPRK1PDE4D | |
| SCHEMBL5664178 | 0.86 | PTAFR (0.48) | PTAFROPRK1PDE4D | |
| SCHEMBL5666605 | 0.85 | PTAFR (0.46) | PTAFROPRK1PDE4D | |
| SCHEMBL5664306 | 0.85 | PTAFR (0.43) | PTAFROPRK1PDE4D | |
| SCHEMBL5665941 | 0.85 | PTAFR (0.42) | PTAFROPRK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7015213-B1 | Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2006-03-21 | — | — | US | claimed |
| US-7015213-B1 | Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2006-03-21 | — | — | US | disclosed |
| US-6987105-B2 | Synthesis and use of thienotriazolodiazepines | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2006-01-17 | — | — | US | disclosed |
| US-20030229078-A1 | Synthesis and use of thienotriazolodiazepines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-12-11 | — | — | US | disclosed |
| US-5492906-A | ANTIASTHMATICS, ANTIALLERGENS, GASTROINTESTINAL PROTECTORS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1996-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229078-A1 | Synthesis and use of thienotriazolodiazepines | TBXAS1, TBXA2R, P2RY10 | PTAFR 5/4885OPRK1 1353/4885PDE4D 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.