Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | NOS2 | P35228 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29601133 | 0.78 | CCR1 (0.55) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL1208300 | 0.78 | CCR1 (0.55) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL29136924 | 0.77 | THRB (0.51) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL7330317 | 0.76 | CCR1 (0.57) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL2830917 | 0.76 | CCR1 (0.44) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL29879467 | 0.76 | CCR1 (0.44) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL2830915 | 0.76 | CCR1 (0.44) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL2624147 | 0.75 | KDM4E (0.54) | PLAUNOS3NOS1NOS2CCR1 | |
| Urea SCHEMBL27918811 | 0.75 | NOS3 (0.53) | PLAUNOS3NOS1NOS2CCR1 | |
| SCHEMBL931557 | 0.74 | CCR1 (0.55) | PLAUNOS3NOS1NOS2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |