Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830915 | 0.86 | CCR1 (0.44) | KDM4EMAPK1NPSR1CCR1CCR5 | |
| SCHEMBL29879467 | 0.86 | CCR1 (0.44) | KDM4EMAPK1NPSR1CCR1CCR5 | |
| SCHEMBL2830917 | 0.86 | CCR1 (0.44) | KDM4EMAPK1NPSR1CCR1CCR5 | |
| SCHEMBL12501426 | 0.83 | PTGS2 (0.44) | KDM4EMAPK1NPSR1CCR1CCR5 | |
| SCHEMBL2956493 | 0.78 | SMN1; SMN2 (0.42) | THRBKDM4ENPSR1CCR1CCR5 | |
| SCHEMBL2956488 | 0.78 | SMN1; SMN2 (0.42) | THRBKDM4ENPSR1CCR1CCR5 | |
| SCHEMBL9756904 | 0.78 | ALDH1A1 (0.63) | THRBKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9756901 | 0.78 | ALDH1A1 (0.63) | THRBKDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1124202 | 0.77 | THRB (0.59) | THRBATMKDM4EMAPK1ALDH1A1 | |
| SCHEMBL5664366 | 0.77 | PLAU (0.50) | KDM4EMAPK1NPSR1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |