Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664570 | 0.86 | ALDH1A1 (0.40) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 | |
| SCHEMBL5004389 | 0.79 | GAA (0.41) | ALDH1A1SMN1; SMN2HPGDNPC1L3MBTL1 | |
| SCHEMBL5664714 | 0.78 | G6PC1 (0.47) | CYP1A2KDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5664934 | 0.74 | CHRM2 (0.40) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 | |
| SCHEMBL5666577 | 0.74 | CHRM2 (0.42) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 | |
| SCHEMBL5664796 | 0.73 | TUBB4A (0.39) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 | |
| SCHEMBL5663580 | 0.73 | CHRM2 (0.44) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 | |
| SCHEMBL5665183 | 0.71 | KDM4E (0.36) | CYP1A2CYP2C19CHRM2CHRM4CHRM5 | |
| SCHEMBL176731 | 0.71 | MEN1 (0.56) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL3909699 | 0.69 | MEN1 (0.48) | CYP1A2CYP2C19KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |