Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 2/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664193 | 0.96 | ALOX12 (0.52) | HTTSMN1; SMN2ALOX12NAAAMALT1 | |
| SCHEMBL5665955 | 0.95 | ALOX12 (0.54) | HTTSMN1; SMN2ALOX12NAAAALDH1A1 | |
| SCHEMBL5664582 | 0.92 | MALT1 (0.46) | HTTSMN1; SMN2ALOX12TSHRMALT1 | |
| SCHEMBL5664737 | 0.86 | SMN1; SMN2 (0.43) | HTTSMN1; SMN2ALOX12TSHRMALT1 | |
| SCHEMBL5666961 | 0.85 | MALT1 (0.42) | HTTSMN1; SMN2MALT1CYP2D6CYP2C19 | |
| SCHEMBL5664731 | 0.85 | MALT1 (0.43) | SMN1; SMN2ALOX12NAAAMALT1ALDH1A1 | |
| SCHEMBL5666551 | 0.81 | HTT (0.53) | HTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5664725 | 0.80 | ALDH1A1 (0.52) | HTTSMN1; SMN2TSHRLMNAMALT1 | |
| SCHEMBL5664960 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2MALT1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL4986402 | 0.78 | NAAA (0.61) | HTTTSHRLMNAPAX8NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |