Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725573 | 0.84 | ACE (0.48) | CYP1A2CYP2C19 | |
| SCHEMBL30388348 | 0.82 | LMNA (0.62) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL5661937 | 0.82 | LMNA (0.54) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL9637755 | 0.80 | MAOB (0.59) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL7688711 | 0.78 | LMNA (0.72) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL9634739 | 0.78 | LMNA (0.72) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL27038087 | 0.78 | LMNA (0.72) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Benzylphenylether SCHEMBL10474044 | 0.77 | LMNA (0.64) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL5661941 | 0.77 | LTA4H (0.59) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| Benzylphenylether SCHEMBL16443386 | 0.76 | LMNA (0.58) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313754-A4 | NUCLEOPHILE-STABLE THIOESTER GENERATING COMPOUNDS, METHODS OF PRODUCTION AND USE | GRYPHON THERAPEUTICS INC (US) | 2006-09-27 | — | — | EP | disclosed |
| US-6977292-B2 | Nucleophile-stable thioester generating compounds, methods of production and use | GRYPHON THERAPEUTICS (US) | 2005-12-20 | — | — | US | disclosed |
| CN-1451013-A | Nucleophile-stable thoester generating compounds, method of production and use | GRYPHON SCIENCES (US) | 2003-10-22 | — | — | CN | disclosed |
| US-20030149234-A1 | Nucleophile-stable thioester generating compounds, methods of production and use | ASTRAZENECA PHARMACEUTICALS LP | 2003-08-07 | — | — | US | disclosed |
| EP-1313754-A1 | NUCLEOPHILE-STABLE THIOESTER GENERATING COMPOUNDS, METHODS OF PRODUCTION AND USE | Gryphon Therapeutics, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018417-A1 | NUCLEOPHILE-STABLE THIOESTER GENERATING COMPOUNDS, METHODS OF PRODUCTION AND USE | GRYPHON THERAPEUTICS, INC. (US) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149234-A1 | Nucleophile-stable thioester generating compounds, methods of production and use | PTMS, COASY, TST | LMNA 4221/4885CYP1A2 3984/4885PTGS1 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.