SCHEMBL5666378

SCHEMBL5666378

COP(C)(=O)OCC(=O)C=Cc1cc(C(C)(C)C)cc(C(C)(C)C)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.44
BACE1 P56817 4/20 0.40
MAPT P10636 3/20 0.37
HSD17B10 Q99714 3/20 0.37
TP53 P04637 2/20 0.37
CYP3A4 P08684 2/20 0.37
ALOX15 P16050 2/20 0.37
MAPK1 P28482 2/20 0.37
CASP7 P55210 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
BLM P54132 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CYP1A2 P05177 2/20 0.36
NFE2L2 Q16236 3/20 0.35
GABBR2 O75899 1/20 0.35
GABBR1 Q9UBS5 1/20 0.35
PTGES O14684 2/20 0.35
ALOX5 P09917 2/20 0.35
PTGS1 P23219 2/20 0.35
STAT3 P40763 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6917719 0.85 GABBR2 (0.52) HMGCRBACE1CYP1A2NFE2L2GABBR2
SCHEMBL6916345 0.84 TNFRSF1A (0.47) HMGCRBACE1HSD17B10NFE2L2GABBR2
SCHEMBL5663346 0.81 HMGCR (0.50) HMGCRBACE1MAPTHSD17B10TP53
SCHEMBL5662810 0.79 RXRA (0.38) HMGCRBACE1NFE2L2ALOX5APP
SCHEMBL9224042 0.78 GABBR2 (0.47) HMGCRBACE1MAPTHSD17B10TP53
SCHEMBL5668606 0.77 HMGCR (0.39) HMGCRBACE1MAPTHSD17B10TP53
SCHEMBL5665784 0.76 BACE1 (0.40) HMGCRBACE1MAPTHSD17B10TP53
SCHEMBL5663559 0.75 HMGCR (0.41) HMGCRBACE1MAPTHSD17B10TP53
SCHEMBL6685293 0.75 HMGCR (0.41) HMGCRBACE1MAPTHSD17B10TP53
SCHEMBL6914399 0.74 ALOX5 (0.37) BACE1MAPTHSD17B10TP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551418-A4 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RES SARL (CH) 2006-05-03 EP claimed
JP-2006504697-A 2006-02-09 JP claimed
EP-1551418-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY Ilex Oncology Research Sàrl (CH) 2005-07-13 EP claimed
WO-2004026243-A2 THERAPEUTIC USES OF LINEAR KETOPHOSPHONATES ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO claimed
WO-2004026315-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO claimed
WO-2004026242-A2 SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO claimed
EP-1551418-A4 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RES SARL (CH) 2006-05-03 EP disclosed
EP-1551418-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY Ilex Oncology Research Sàrl (CH) 2005-07-13 EP disclosed
WO-2004026243-A2 THERAPEUTIC USES OF LINEAR KETOPHOSPHONATES ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026315-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026242-A2 SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed