Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL11807410 | 0.95 | TSHR (0.52) | TSHRALDH1A1LMNACA5ACA5B | |
| Aniline SCHEMBL28246646 | 0.91 | TSHR (0.48) | TSHRALDH1A1LMNACA9CA12 | |
| Aniline SCHEMBL29084431 | 0.85 | CYP19A1 (0.45) | TSHRALDH1A1PBRM1MAPK1MAPT | |
| Nitric Acid SCHEMBL28465132 | 0.81 | ALOX15 (0.56) | TSHRALDH1A1LMNACA5ACA5B | |
| Nitrobenzene SCHEMBL718033 | 0.80 | ALDH1A1 (0.76) | TSHRALDH1A1LMNACA5ACA5B | |
| Aniline SCHEMBL22528486 | 0.80 | TSHR (0.92) | TSHRALDH1A1CA9CA12CA1 | |
| Benzidine SCHEMBL27858206 | 0.79 | TDP1 (0.58) | TSHRALDH1A1LMNACA5ACA5B | |
| Biphenyl SCHEMBL27821216 | 0.78 | CRHBP (0.56) | TSHRALDH1A1LMNACA5ACA5B | |
| Aniline SCHEMBL6049858 | 0.77 | TSHR (0.73) | TSHRALDH1A1HSD17B10CYP3A4TAAR1 | |
| Aniline SCHEMBL8413315 | 0.77 | TSHR (0.73) | TSHRALDH1A1HSD17B10CYP3A4TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232905-B2 | Substituted dihydropyrimidinone preparation using polyaniline salt catalyst | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-06-19 | — | — | US | claimed |
| EP-1462448-B1 | Process for preparing substituted coumarins | COUNCIL SCIENT IND RES (IN) | 2006-05-10 | — | — | EP | claimed |
| US-6982345-B2 | Process for preparation of cinnamates using polyaniline salts as catalysts | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2006-01-03 | — | — | US | claimed |
| US-20050215790-A1 | Substituted dihydropyrimidinone preparation using polyaniline salt catalyst | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-09-29 | — | — | US | claimed |
| WO-2005063719-A1 | SUBSTITUTED DIHYDROPYRIMIDINONE PREPARATION USING POLYANILINE SALT CATALYST | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2005-07-14 | — | — | WO | claimed |
| EP-1462448-A1 | Process for preparing substituted coumarins | Council of Scientific and Industrial Research (IN) | 2004-09-29 | — | — | EP | claimed |
| US-6743942-B1 | ENVIRONMENTAL SAFETY; EASY SEPARATION, REGENERATION AND REUSE | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2004-06-01 | — | — | US | claimed |
| US-20040092763-A1 | PROCESS FOR THE TRANSESTERIFICATION OF KETO ESTER WITH ALCOHOL USING POLYANILINE SALTS AS CATALYST | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH | 2004-05-13 | — | — | US | claimed |
| US-6716996-B1 | POLYANILINE SALT CATALYTIC CYCLIZATION OF PHENOL AND KETO ESTER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-04-06 | — | — | US | claimed |
| US-20040049068-A1 | Process for preparation of cinnamates using polyaniline salts as catalysts | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2004-03-11 | — | — | US | claimed |
| CN-1398794-A | Treatment of water containing waste organic matter with nitrate of aromatic amine | AIR PROD & CHEM (US) | 2003-02-26 | — | — | CN | claimed |
| WO-2002079138-A1 | A PROCESS FOR PREPARATION OF AN ESTER USING A POLYANALINE SALT AS CATALYST | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2002-10-10 | — | — | WO | claimed |
| US-6350896-B1 | POLYANILINE SALTS WITH HYDROCHLORIC ACID OR CARBOXYLIC ACIDS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2002-02-26 | — | — | US | claimed |
| CN-120099528-A | Preparation method and application of upward continuous casting oxygen-free copper rod antioxidant | 湘潭新煌新材料有限公司 | 2025-06-06 | — | — | CN | disclosed |
| US-20140185123-A1 | MANUFACTURING METHOD OF ELECTROCHROMIC WORKING ELECTRODE AND ELECTROCHROMIC DEVICE | BOE TECHNOLOGY GROUP CO., LTD. (CN) | 2014-07-03 | — | — | US | disclosed |
| US-7232905-B2 | Substituted dihydropyrimidinone preparation using polyaniline salt catalyst | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-06-19 | — | — | US | disclosed |
| US-6350896-B1 | POLYANILINE SALTS WITH HYDROCHLORIC ACID OR CARBOXYLIC ACIDS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2002-02-26 | — | — | US | disclosed |
| US-RE33168-E | Nitration processes | Gross, Jerome A. (US) | 1990-02-20 | — | — | US | disclosed |
| US-4621157-A | DINITRATION OF SUBSTITUTED ANILINE | Gross, Jerome A. (US) | 1986-11-04 | — | — | US | disclosed |
| US-4058608-A | FUNGICIDES | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1977-11-15 | — | — | US | disclosed |