Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5664615 | 0.96 | KCNA5 (0.46) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL5663585 | 0.91 | KCNA5 (0.51) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL5664573 | 0.85 | ALDH1A1 (0.46) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL12663367 | 0.84 | CYP1A2 (0.45) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL15730896 | 0.83 | CYP2C19 (0.47) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL5664359 | 0.79 | KDM4E (0.44) | KCNH2CYP1A2TSHRKDM4ERAB9A | |
| SCHEMBL5664800 | 0.79 | ALDH1A1 (0.48) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL5664937 | 0.78 | KCNA5 (0.51) | KCNA5KCNH2CYP2D6KCNE1CYP2C19 | |
| SCHEMBL5664717 | 0.78 | HPGD (0.51) | CYP2C19ALDH1A1CYP1A2TSHRKDM4E | |
| SCHEMBL5664193 | 0.75 | ALOX12 (0.52) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |