Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDXK | O00764 | 1/20 | 0.33 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576456 | 0.80 | ESR1 (0.52) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL4577063 | 0.80 | KDM4E (0.51) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL5666549 | 0.77 | PNPO (0.38) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL27581870 | 0.72 | KDM4E (0.50) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL13494528 | 0.71 | KDM4E (0.41) | KDM4EALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL28558160 | 0.71 | KDM4E (0.49) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL29941196 | 0.68 | ESR1 (0.43) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL4577607 | 0.67 | HPGD (0.51) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL4576376 | 0.66 | KDM4E (0.50) | PNPOESR1PTGS1ACP1PDE4A | |
| SCHEMBL2260982 | 0.65 | KDM4E (0.43) | PNPOESR1PTGS1ACP1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060241083-A1 | Novel heteroaryl phosphonates as cardioprotective agents | MEDICURE INTERNATIONAL INC. (IN) | 2006-10-26 | — | — | US | claimed |
| EP-1606295-A1 | HETEROARYL PHOSPHONATES, COMPOSITIONS CONTAINING THEM AND METHODS OF TREATMENT OF VARIOUS DISORDERS USING THEM | Medicure Inc. (CA) | 2005-12-21 | — | — | EP | claimed |
| WO-2004083222-A1 | NOVEL HETEROARYL PHOSPHONATES AS CARDIOPROTECTIVE AGENTS | MEDICURE INC. (CA) | 2004-09-30 | — | — | WO | claimed |
| US-20040186077-A1 | Novel heteroaryl phosphonates as cardioprotective agents | MEDICURE INTERNATIONAL INC. (BB) | 2004-09-23 | — | — | US | claimed |
| US-20060241083-A1 | Novel heteroaryl phosphonates as cardioprotective agents | MEDICURE INTERNATIONAL INC. (IN) | 2006-10-26 | — | — | US | disclosed |
| EP-1606295-A1 | HETEROARYL PHOSPHONATES, COMPOSITIONS CONTAINING THEM AND METHODS OF TREATMENT OF VARIOUS DISORDERS USING THEM | Medicure Inc. (CA) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004083222-A1 | NOVEL HETEROARYL PHOSPHONATES AS CARDIOPROTECTIVE AGENTS | MEDICURE INC. (CA) | 2004-09-30 | — | — | WO | disclosed |
| US-20040186077-A1 | Novel heteroaryl phosphonates as cardioprotective agents | MEDICURE INTERNATIONAL INC. (BB) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186077-A1 | Novel heteroaryl phosphonates as cardioprotective agents | TNNT2, TNNI3, ADRB3 | PNPO 937/4885ESR1 2144/4885PTGS1 315/4885 |
| US-20060241083-A1 | Novel heteroaryl phosphonates as cardioprotective agents | TNNI3, TNNT2, FABP3 | PNPO 1107/4885ESR1 4074/4885PTGS1 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.