Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | ACP1 | P24666 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.52 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.49 |
| ▸ | PDXK | O00764 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | PNPO | Q9NVS9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8835556 | 0.83 | KDM4E (0.59) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL17224491 | 0.80 | KDM4E (0.56) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL5667259 | 0.80 | PNPO (0.39) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL2467030 | 0.79 | KDM4E (0.54) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL6045299 | 0.79 | KDM4E (0.54) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL2692050 | 0.78 | P2RX2 (0.56) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL14687825 | 0.78 | KDM4E (0.53) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL3800949 | 0.77 | P2RX2 (0.54) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL9274513 | 0.75 | ESR1 (0.68) | ESR1PTGS1ACP1PDE4AP2RX1 | |
| SCHEMBL4577063 | 0.75 | KDM4E (0.51) | ESR1PTGS1ACP1PDE4AP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080311099-A1 | Pyridoxal-5-Phosphate and Related Compounds in Combination With Therapeutic Cardiovascular Compounds for Treating Angina | MEDICURE INTERNATIONAL INC. | 2008-12-18 | — | — | US | disclosed |
| US-7442689-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2008-10-28 | — | — | US | disclosed |
| EP-1531157-B1 | Cardioprotective phosphonates | MEDICURE INT INC (BB) | 2008-03-19 | — | — | EP | disclosed |
| US-20070167411-A1 | Compositions for treating angina | MEDICURE INTERNATIONAL INC. (BB) | 2007-07-19 | — | — | US | disclosed |
| EP-1796685-A1 | PYRIDOXAL-5´-PHOSPHATE AND RELATED COMPOUNDS IN COMBINATION WITH THERAPEUTIC CADIOVASCULAR COMPOUNDS FOR TREATING ANGINA. | Medicure International Inc. (CA) | 2007-06-20 | — | — | EP | disclosed |
| US-7198648-B2 | Coupling component for oxidative hair dyes | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2007-04-03 | — | — | US | disclosed |
| US-20070032456-A1 | Modulation of cell death | MEDICURE INC. (CA) | 2007-02-08 | — | — | US | disclosed |
| US-7105673-B2 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (BB) | 2006-09-12 | — | — | US | disclosed |
| WO-2006058411-A1 | PYRIDOXAL-5´-PHOSPHATE AND RELATED COMPOUNDS IN COMBINATION WITH THERAPEUTIC CADIOVASCULAR COMPOUNDS FOR TREATING ANGINA. | MEDICURE INTERNATIONAL INC. (CA) | 2006-06-08 | — | — | WO | disclosed |
| EP-1610783-A2 | MODULATION OF CELL DEATH | Medicure Inc. (CA) | 2006-01-04 | — | — | EP | disclosed |
| EP-1292266-A2 | NOVEL COUPLING COMPONENT FOR OXIDATIVE HAIR DYES | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-03-19 | — | — | EP | disclosed |
| EP-1292263-A2 | VITAMIN B6 DERIVATIVES AS PROTECTIVE COMPONENTS IN THE OXIDATIVE TREATMENT OF HAIR | Henkel Kommanditgesellschaft auf Aktien (DE) | 2003-03-19 | — | — | EP | disclosed |
| EP-1278526-A2 | TREATMENT OF CEREBROVASCULAR DISEASE | Medicure International Inc. (BB) | 2003-01-29 | — | — | EP | disclosed |
| EP-1268498-A1 | CARDIOPROTECTIVE PHOSPHONATES AND MALONATES | Medicure International Inc. (BB) | 2003-01-02 | — | — | EP | disclosed |
| US-20020010158-A1 | Cardioprotective phosphonates and malonates | MEDICURE INTERNATIONAL INC. (CA) | 2002-01-24 | — | — | US | disclosed |
| WO-2001097756-A2 | NOVEL COUPLING COMPONENT FOR OXIDATIVE HAIR DYES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-12-27 | — | — | WO | disclosed |
| US-20010056081-A1 | Treatment of cerebrovascular disease | MEDICURE INTERNATIONAL INC. (CA) | 2001-12-27 | — | — | US | disclosed |
| WO-2001097755-A2 | VITAMIN B6 DERIVATIVES AS PROTECTIVE COMPONENTS IN THE OXIDATIVE TREATMENT OF HAIR | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001072309-A2 | TREATMENT OF CEREBROVASCULAR DISEASE | MEDICURE INTERNATIONAL INC. (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2001064692-A1 | CARDIOPROTECTIVE PHOSPHONATES AND MALONATES | MEDICURE INTERNATIONAL INC. (BB) | 2001-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167411-A1 | Compositions for treating angina | PNPO, PYGM, PLPBP | ESR1 3953/4885PTGS1 330/4885ACP1 649/4885 |
| US-20080311099-A1 | Pyridoxal-5-Phosphate and Related Compounds in Combination With Therapeutic Cardiovascular Compounds for Treating Angina | ALOX5, PNPO, KCNMB1 | ESR1 4362/4885PTGS1 372/4885ACP1 1423/4885 |
| US-20020010158-A1 | Cardioprotective phosphonates and malonates | PDXK, PHOSPHO1, PNPO | ESR1 3532/4885PTGS1 873/4885ACP1 371/4885 |
| US-20010056081-A1 | Treatment of cerebrovascular disease | PNPO, PLPBP, VNN1 | ESR1 4867/4885PTGS1 498/4885ACP1 710/4885 |
| US-20070032456-A1 | Modulation of cell death | CASP6, CASP3, CASP5 | ESR1 4874/4885PTGS1 834/4885ACP1 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.