Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 9/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA3 | P07451 | 2/20 | 0.30 |
| ▸ | CA4 | P22748 | 2/20 | 0.30 |
| ▸ | CA6 | P23280 | 2/20 | 0.30 |
| ▸ | CA5A | P35218 | 2/20 | 0.30 |
| ▸ | CA7 | P43166 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23451676 | 0.82 | NFKB1 (0.40) | DNM1TSHRNFKB1FDPSPDE3A | |
| SCHEMBL23451670 | 0.79 | NFKB1 (0.38) | DNM1TSHRNFKB1FDPSPDE3A | |
| SCHEMBL60278 | 0.77 | TSHR (0.35) | TSHRALDH1A1FDPSLMNA | |
| SCHEMBL10664860 | 0.74 | — | — | |
| SCHEMBL5706629 | 0.74 | — | — | |
| SCHEMBL29064055 | 0.72 | TSHR (0.44) | TSHRFDPS | |
| SCHEMBL1018876 | 0.72 | TSHR (0.44) | TSHRFDPS | |
| SCHEMBL8670374 | 0.72 | TSHR (0.44) | TSHRFDPS | |
| SCHEMBL3951633 | 0.71 | — | — | |
| SCHEMBL9237381 | 0.71 | TSHR (0.35) | TSHRALDH1A1FDPSLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393614-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | UNIV DUKE (US) | 2021-12-23 | — | — | US | claimed |
| CN-112823006-A | Quinone reductase 2 inhibitors as neuroprotective agents | 杜克大学 | 2021-05-18 | — | — | CN | claimed |
| WO-2020081678-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | DUKE UNIVERSITY (US) | 2020-04-23 | — | — | WO | claimed |
| US-20060074105-A1 | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 | SERENEX, INC. (US) | 2006-04-06 | — | — | US | claimed |
| WO-2006034235-A2 | SUBSTITUTED QUINOLINE AND QUINAZOLINE INHIBITORS OF QUINONE REDUCTASE 2 | SERENEX, INC. (US) | 2006-03-30 | — | — | WO | claimed |
| US-20210393614-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | UNIV DUKE (US) | 2021-12-23 | — | — | US | disclosed |
| CN-112823006-A | Quinone reductase 2 inhibitors as neuroprotective agents | 杜克大学 | 2021-05-18 | — | — | CN | disclosed |
| WO-2020081678-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | DUKE UNIVERSITY (US) | 2020-04-23 | — | — | WO | disclosed |
| US-20060074105-A1 | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 | SERENEX, INC. (US) | 2006-04-06 | — | — | US | disclosed |
| WO-2006034235-A2 | SUBSTITUTED QUINOLINE AND QUINAZOLINE INHIBITORS OF QUINONE REDUCTASE 2 | SERENEX, INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074105-A1 | Substituted quinoline and quinazoline inhibitors of quinone reductase 2 | NQO2, QTRT1, QTRT2 | DNM1 1313/4885TSHR 3791/4885MEN1 2864/4885 |
| US-20210393614-A1 | QUINONE REDUCTASE 2 INHIBITORS FOR USE AS NEUROPROTECTIVE AGENTS | NQO1, TXNRD2, NQO2 | DNM1 2325/4885TSHR 3982/4885MEN1 2512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.