SCHEMBL5667474

SCHEMBL5667474

CCOc1cc(/C=C/C(=O)C(C)(C)P(=O)(O)O)cc(OCC)c1O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2A P11388 1/20 0.45
CYP1A2 P05177 5/20 0.42
CYP2D6 P10635 4/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2B6 P20813 1/20 0.42
PTGS1 P23219 2/20 0.41
PKM P14618 1/20 0.41
PTGS2 P35354 1/20 0.41
ALOX5 P09917 3/20 0.41
CYP1A1 P04798 3/20 0.41
CYP1B1 Q16678 3/20 0.41
STAT3 P40763 2/20 0.39
NFE2L2 Q16236 2/20 0.39
PTGES O14684 1/20 0.39
KDM4E B2RXH2 3/20 0.39
KMT2A Q03164 3/20 0.39
GAA P10253 1/20 0.39
MET P08581 1/20 0.39
NFKB1 P19838 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5667477 1.00 TOP2A (0.45) TOP2ACYP1A2CYP2D6CYP3A4CYP2C9
SCHEMBL5669061 0.87 CYP1A2 (0.43) TOP2ACYP1A2CYP2D6CYP3A4CYP2C9
SCHEMBL5669057 0.87 CYP1A2 (0.43) TOP2ACYP1A2CYP2D6CYP3A4CYP2C9
SCHEMBL6670542 0.78 ALOX5 (0.51) CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6
SCHEMBL5665894 0.78 CYP1A2 (0.51) CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6
SCHEMBL7063102 0.77 CYP1A2 (0.57) CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6
SCHEMBL7063106 0.77 CYP1A2 (0.57) CYP1A2CYP2D6CYP3A4CYP2C9CYP2B6
SCHEMBL27823447 0.77 PKM (0.68) TOP2ACYP1A2CYP2D6CYP3A4CYP2C9
SCHEMBL27823448 0.77 PKM (0.68) TOP2ACYP1A2CYP2D6CYP3A4CYP2C9
SCHEMBL5667595 0.77 ALDH1A1 (0.59) CYP1A2CYP2D6CYP1A1CYP1B1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551418-A4 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RES SARL (CH) 2006-05-03 EP disclosed
EP-1551418-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY Ilex Oncology Research Sàrl (CH) 2005-07-13 EP disclosed
WO-2004026315-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026243-A2 THERAPEUTIC USES OF LINEAR KETOPHOSPHONATES ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026242-A2 SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed