Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | TP53 | P04637 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9042466 | 0.84 | KDM4E (0.81) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL5667542 | 0.79 | KDM4E (0.65) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL30714903 | 0.78 | THRB (0.63) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL5615796 | 0.77 | KDM4E (0.62) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL27742119 | 0.76 | RAB9A (0.61) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL13833632 | 0.74 | KDM4E (0.58) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL9871137 | 0.74 | ALDH1A1 (0.49) | KDM4ERAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2246115 | 0.74 | MAPT (1.00) | KDM4EMAPTTP53RAB9AMEN1 | |
| SCHEMBL7470729 | 0.73 | KDM4E (0.46) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL2243594 | 0.71 | TP53 (1.00) | KDM4EMAPTTP53RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076104-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2007-07-05 | — | — | WO | disclosed |