Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31404243 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2LIN28ATDP1APP | |
| SCHEMBL343360 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2LIN28ATDP1APP | |
| SCHEMBL16590461 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2LIN28ATDP1APP | |
| SCHEMBL18549341 | 0.84 | MAPT (0.65) | MAPTSMN1; SMN2LIN28ATDP1APP | |
| SCHEMBL18549333 | 0.84 | MAPT (0.65) | MAPTSMN1; SMN2LIN28ATDP1APP | |
| SCHEMBL16571639 | 0.81 | MAPT (0.56) | MAPTSMN1; SMN2LIN28ATDP1APP | |
| SCHEMBL30576433 | 0.81 | ALOX5 (0.56) | MAPTSMN1; SMN2ALOX5KDM4ELMNA | |
| SCHEMBL1846872 | 0.81 | ALOX5 (0.56) | MAPTSMN1; SMN2ALOX5KDM4ELMNA | |
| SCHEMBL12475666 | 0.80 | TYR (0.60) | MAPTTDP1ALOX5KDM4ELMNA | |
| SCHEMBL18549343 | 0.79 | MAPT (0.58) | MAPTSMN1; SMN2LIN28ATDP1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7018840-B2 | Ligand for in the detection of toxic metals in mammals | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2006-03-28 | — | — | US | disclosed |
| US-20030008405-A1 | Fluorescent metal sensors, and methods of making and using the same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-01-09 | — | — | US | disclosed |