Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669917 | 0.75 | PLAU (0.53) | HDAC1PLAU | |
| SCHEMBL13993519 | 0.74 | KDM4E (0.48) | ALDH1A1PLAUNAAA | |
| SCHEMBL5669914 | 0.74 | KDM4E (0.48) | ALDH1A1PLAUNAAA | |
| SCHEMBL10698289 | 0.66 | EPHX1 (0.49) | HDAC1HDAC6NAAA | |
| SCHEMBL14046197 | 0.66 | CYP1A2 (0.57) | ALDH1A1MAPTHPGDNPC1RAB9A | |
| SCHEMBL28666105 | 0.66 | NPC1 (0.62) | HDAC1HDAC6ALDH1A1HPGDNAAA | |
| SCHEMBL1624886 | 0.65 | F10 (0.54) | HDAC1HDAC6ALDH1A1HPGDF2 | |
| SCHEMBL11506563 | 0.65 | ADRA2C (0.58) | HDAC1HDAC6ALDH1A1MAPTADRB2 | |
| SCHEMBL11506841 | 0.65 | ALDH1A1 (0.63) | HDAC1HDAC6ALDH1A1MAPTADRB2 | |
| SCHEMBL5821101 | 0.65 | NPC1 (0.57) | HDAC1HDAC6ALDH1A1HPGDNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716137-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | Pfizer Products Incorporated (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080373-A1 | SUBSTITUTED QUINOLINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-09-01 | — | — | WO | disclosed |