Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.72 |
| ▸ | KDM5C | P41229 | 3/20 | 0.72 |
| ▸ | KDM6B | O15054 | 2/20 | 0.72 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.72 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.72 |
| ▸ | KDM4A | O75164 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CCR1 | P32246 | 3/20 | 0.50 |
| ▸ | CCR5 | P51681 | 3/20 | 0.50 |
| ▸ | CCR8 | P51685 | 3/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.50 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562841 | 0.84 | KDM4C (1.00) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| Dipyridyl SCHEMBL3941503 | 0.84 | KDM4C (1.00) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| SCHEMBL913277 | 0.84 | KDM4C (1.00) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| Dipyridyl SCHEMBL21551506 | 0.84 | KDM4C (1.00) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| Dipyridyl SCHEMBL3954422 | 0.82 | KDM4C (0.96) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| SCHEMBL902063 | 0.82 | KDM4E (0.72) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| Dipyridyl SCHEMBL8358045 | 0.82 | KDM4C (0.96) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| SCHEMBL8967233 | 0.82 | KDM4E (0.72) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| Benzoic Acid SCHEMBL30567494 | 0.82 | KDM4C (0.96) | KDM4EKDM4CKDM5CKDM6BKDM2A | |
| Dipyridyl SCHEMBL9559929 | 0.81 | KDM4E (0.70) | KDM4EKDM4CKDM5CKDM6BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153854-B2 | Pyrrolopyridazine derivatives | ASTELLAS PHARMA INC. (JP) | 2006-12-26 | — | — | US | disclosed |
| US-20050075342-A1 | Pyrrolopyridazine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075342-A1 | Pyrrolopyridazine derivatives | PDE4A, PDE5A, PDE12 | KDM4E 1703/4885KDM4C 1410/4885KDM5C 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.