Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16306323 | 0.79 | ALOX5 (0.60) | ALOX5DHODHPARP1MEN1KMT2A | |
| SCHEMBL6994884 | 0.78 | GAA (0.44) | ALOX5MEN1KMT2AGAAHTR2B | |
| SCHEMBL5670723 | 0.77 | HTR5A (0.37) | KMT2AGAANPSR1BRD4CREBBP | |
| SCHEMBL5670844 | 0.76 | ALOX5 (0.56) | ALOX5DHODHPARP1MEN1KMT2A | |
| SCHEMBL5673716 | 0.76 | ALOX5 (0.50) | ALOX5DHODHPARP1MEN1KMT2A | |
| SCHEMBL5672804 | 0.76 | ALOX5 (0.50) | ALOX5DHODHPARP1MEN1KMT2A | |
| SCHEMBL7983033 | 0.76 | ALOX5 (0.50) | ALOX5DHODHPARP1MEN1KMT2A | |
| SCHEMBL7000588 | 0.74 | PARP1 (0.37) | ALOX5PARP1GAAMAPTTDP1 | |
| SCHEMBL5670589 | 0.74 | AHR (0.39) | HTR2BHTR7TP53POLBMAPT | |
| SCHEMBL21115127 | 0.74 | ALOX5 (0.65) | ALOX5DHODHPARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980362-B1 | SUBSTITUTED HETEROCYCLES AND THEIR USE IN MEDICAMENTS | SCHERING AG (DE) | 2006-08-16 | — | — | EP | disclosed |
| US-6191127-B1 | ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES, CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0980362-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998050372-A1 | SUBSTITUTED HETEROCYCLES AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-11-12 | — | — | WO | disclosed |