SCHEMBL6994884

SCHEMBL6994884

CC1=C(N)Nc2cc(-c3ccccc3)ccc2O1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.44
KDM4E B2RXH2 4/20 0.44
KMT2A Q03164 4/20 0.44
MEN1 O00255 3/20 0.44
MAPT P10636 3/20 0.38
NPC1 O15118 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
MAOA P21397 3/20 0.37
MAOB P27338 2/20 0.37
PGR P06401 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
BACE1 P56817 1/20 0.35
HSD17B10 Q99714 2/20 0.35
ALDH1A1 P00352 2/20 0.35
HPGD P15428 2/20 0.35
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
HSP90AA1 P07900 1/20 0.35
ALOX15 P16050 1/20 0.35
ALOX12 P18054 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6993120 0.80 KCNH2 (0.44) BACE1HTR7
SCHEMBL7003121 0.80 KCNH2 (0.46) PGR
SCHEMBL5670592 0.78 ALOX5 (0.56) GAAKMT2AMEN1MAPTALOX5
SCHEMBL7000588 0.78 PARP1 (0.37) GAAKDM4EMAPTLMNAALOX5
SCHEMBL5670589 0.76 AHR (0.39) MAPTPGRALDH1A1LMNAALOX15
SCHEMBL22902405 0.75 ALOX5 (0.63) GAAKDM4EKMT2AMEN1MAPT
Hydrochloric Acid SCHEMBL5672533 0.74 AHR (0.38) GAAKMT2AMAPTPGRLMNA
Hydrochloric Acid SCHEMBL7713373 0.74 PARP1 (0.53) KDM4EKMT2AMEN1NPC1ALDH1A1
SCHEMBL7988325 0.73 ALDH1A1 (0.36) GAAKDM4EKMT2AMEN1MAPT
SCHEMBL6999684 0.72 SIGMAR1 (0.49) L3MBTL1ALDH1A1LMNASIGMAR1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP claimed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US claimed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP claimed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO claimed
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed