SCHEMBL5670684

SCHEMBL5670684

CCCCCCC1Oc2ccccc2NC1=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.53
PARP1 P09874 1/20 0.53
ALDH1A1 P00352 3/20 0.52
USP2 O75604 1/20 0.51
BRD4 O60885 1/20 0.49
MAPK1 P28482 1/20 0.49
TSHR P16473 1/20 0.48
HPGD P15428 1/20 0.48
PGR P06401 1/20 0.47
HDAC3 O15379 3/20 0.47
HDAC4 P56524 3/20 0.47
HDAC1 Q13547 3/20 0.47
HDAC7 Q8WUI4 3/20 0.47
HDAC2 Q92769 3/20 0.47
HDAC10 Q969S8 3/20 0.47
HDAC11 Q96DB2 3/20 0.47
HDAC8 Q9BY41 3/20 0.47
HDAC6 Q9UBN7 3/20 0.47
HDAC9 Q9UKV0 3/20 0.47
HDAC5 Q9UQL6 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5670690 0.94 PARP1 (0.55) HSD17B10PARP1ALDH1A1USP2BRD4
SCHEMBL4821188 0.88 PARP1 (0.58) HSD17B10PARP1ALDH1A1USP2BRD4
SCHEMBL7985006 0.83 PGR (0.50) HSD17B10PARP1ALDH1A1USP2BRD4
SCHEMBL30641044 0.83 ALDH1A1 (0.50) HSD17B10PARP1ALDH1A1USP2MAPK1
SCHEMBL22186873 0.82 PARP1 (0.51) HSD17B10PARP1ALDH1A1USP2MAPK1
SCHEMBL9155928 0.82 PARP1 (0.51) HSD17B10PARP1ALDH1A1USP2MAPK1
SCHEMBL3249363 0.82 PARP1 (0.62) HSD17B10PARP1ALDH1A1USP2MAPK1
SCHEMBL10505826 0.81 L3MBTL1 (0.55) HSD17B10USP2BRD4MAPK1TSHR
SCHEMBL3641415 0.80 PARP1 (0.56) HSD17B10PARP1ALDH1A1USP2MAPK1
SCHEMBL2165889 0.79 L3MBTL1 (0.47) HSD17B10USP2BRD4MAPK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0980362-B1 SUBSTITUTED HETEROCYCLES AND THEIR USE IN MEDICAMENTS SCHERING AG (DE) 2006-08-16 EP disclosed
US-6191127-B1 ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES, CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS SCHERING AKTIENGESELLSCHAFT (DE) 2001-02-20 US disclosed
EP-0980362-A1 SUBSTITUTED HETEROCYCLES AND THEIR USE IN MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-02-23 EP disclosed
WO-1998050372-A1 SUBSTITUTED HETEROCYCLES AND THEIR USE IN MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 1998-11-12 WO disclosed