Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672361 | 0.91 | AGTR1 (0.53) | AGTR1GRM5CYP11B1CYP11B2AKR1B1 | |
| SCHEMBL5671824 | 0.85 | AGTR1 (0.45) | HTR2AKCNH2AGTR1GRM5CYP11B1 | |
| SCHEMBL7368039 | 0.80 | GRM5 (0.41) | HTR2AKCNH2GRM5AKR1B1PKM | |
| SCHEMBL4350622 | 0.77 | CA12 (0.58) | HTR2AKCNH2PKMLMNACA12 | |
| SCHEMBL6601315 | 0.74 | HTR2A (0.40) | HTR2AKCNH2GRM5PKMLMNA | |
| SCHEMBL6877909 | 0.73 | GRM5 (0.46) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL28281697 | 0.73 | PKM (0.47) | PKMCA12CA1CA2CA9 | |
| SCHEMBL10834173 | 0.72 | AGTR1 (0.65) | HTR2AKCNH2AGTR1CYP11B1CYP11B2 | |
| SCHEMBL25356808 | 0.70 | HTR2A (0.62) | HTR2AKCNH2AGTR1AKR1B1PKM | |
| SCHEMBL3158170 | 0.70 | HTR2A (0.62) | HTR2AKCNH2AGTR1AKR1B1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7030121-B2 | Pyrazolopyrazine compound and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2006-04-18 | — | — | US | disclosed |
| US-20040152706-A1 | Pyrazolopyrazine compound pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2004-08-05 | — | — | US | disclosed |
| WO-2002100864-A1 | PYRAZOLOPYRAZINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152706-A1 | Pyrazolopyrazine compound pharmaceutical use thereof | ADORA2A, P2RX5, ADORA1 | HTR2A 68/4885KCNH2 36/4885AGTR1 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.