Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 3/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 11/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672153 | 0.88 | CXCR2 (0.44) | MAPTHTTGRNSORT1CXCR2 | |
| SCHEMBL5672212 | 0.86 | MAPT (0.42) | MAPTHTTGRNSORT1CXCR2 | |
| SCHEMBL5672221 | 0.79 | MAPT (0.49) | MAPTHTTGRNSORT1ALDH1A1 | |
| SCHEMBL6825316 | 0.78 | MAPT (0.45) | MAPTHTTGRNSORT1ALDH1A1 | |
| SCHEMBL7067901 | 0.69 | ESR1 (0.40) | CXCR2 | |
| SCHEMBL6825770 | 0.69 | ESR1 (0.40) | CXCR2 | |
| SCHEMBL6508736 | 0.67 | NPR3 (0.53) | — | |
| SCHEMBL6508740 | 0.67 | NPR3 (0.53) | — | |
| SCHEMBL5672887 | 0.67 | CXCR2 (0.54) | MAPTCXCR2ALDH1A1 | |
| SCHEMBL5672899 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037916-B2 | Pyrimidine derivatives as IL-8 receptor antagonists | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2006-05-02 | — | — | US | disclosed |
| WO-2004062609-A2 | PYRIMIDINE DERIVATIVES AS IL-8 RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| US-20040087601-A1 | Pyrimidine derivatives as IL-8 receptor antagonists | PHARMACOPEIA, LLC | 2004-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087601-A1 | Pyrimidine derivatives as IL-8 receptor antagonists | CXCL8, IL1RN, IL18 | MAPT 4048/4885HTT 4337/4885GRN 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.