Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 4/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838875 | 0.76 | SCN4A (0.65) | SCN4AMAOAPTGS1LMNAMTNR1A | |
| SCHEMBL14499008 | 0.76 | SCN4A (0.65) | SCN4AMAOAPTGS1LMNAMTNR1A | |
| SCHEMBL96547 | 0.76 | LMNA (0.57) | SCN4AMAOAPTGS1LMNAMTNR1A | |
| SCHEMBL4212363 | 0.76 | LMNA (0.57) | SCN4ALMNAALOX15MTNR1AMTNR1B | |
| SCHEMBL14401030 | 0.73 | TACR1 (0.54) | CA1CA2CA7CA9CYP1A2 | |
| SCHEMBL13354771 | 0.73 | TACR1 (0.54) | CA1CA2CA7CA9CYP1A2 | |
| SCHEMBL10547420 | 0.72 | SCN4A (0.61) | SCN4AMAOAPTGS1LMNAMTNR1A | |
| SCHEMBL507119 | 0.72 | LMNA (0.63) | SCN4AMAOAPTGS1LMNAMTNR1A | |
| SCHEMBL1369854 | 0.72 | LMNA (0.63) | SCN4AMAOAPTGS1LMNATAAR1 | |
| SCHEMBL366154 | 0.72 | LMNA (0.63) | SCN4AMAOAPTGS1LMNAMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906091-B1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-10-04 | — | — | EP | disclosed |
| EP-0906091-A4 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-0906091-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997036580-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-10-09 | — | — | WO | disclosed |