Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.47 |
| ▸ | TGM2 | P21980 | 9/20 | 0.44 |
| ▸ | F13A1 | P00488 | 8/20 | 0.44 |
| ▸ | TGM1 | P22735 | 7/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987296 | 0.86 | ROCK2 (0.59) | ROCK2ROCK1P2RX7MEN1CIT | |
| SCHEMBL567678 | 0.85 | CKS1B (0.47) | ROCK2TGM2F13A1TGM1ROCK1 | |
| SCHEMBL567211 | 0.83 | ROCK2 (0.44) | ROCK2ROCK1P2RX7MEN1PRKD3 | |
| SCHEMBL566233 | 0.83 | ROCK2 (0.44) | ROCK2ROCK1P2RX7MEN1PRKD3 | |
| SCHEMBL566234 | 0.83 | ROCK2 (0.44) | ROCK2ROCK1P2RX7MEN1PRKD3 | |
| SCHEMBL567120 | 0.81 | ROCK2 (0.42) | ROCK2ROCK1P2RX7MEN1PRKD3 | |
| SCHEMBL567121 | 0.81 | ROCK2 (0.42) | ROCK2ROCK1P2RX7MEN1PRKD3 | |
| SCHEMBL568155 | 0.80 | ATM (0.50) | ROCK2TGM2F13A1TGM1ROCK1 | |
| SCHEMBL567385 | 0.78 | ATM (0.50) | ROCK2TGM2F13A1TGM1ROCK1 | |
| SCHEMBL8097444 | 0.77 | MEN1 (0.42) | ROCK2TGM2F13A1TGM1TGM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT1A1, SULT1E1, SULT2A1 | ROCK2 1689/4885TGM2 3697/4885F13A1 2247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.