Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 8/20 | 0.55 |
| ▸ | MMP13 | P45452 | 8/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964392 | 0.99 | MMP1 (0.56) | USP2HTTSMN1; SMN2MMP1MMP13 | |
| SCHEMBL643982 | 0.89 | MMP1 (0.55) | USP2HTTSMN1; SMN2MMP1MMP13 | |
| SCHEMBL6960331 | 0.86 | MMP1 (0.72) | MMP1MMP13MMP2CA1CA2 | |
| SCHEMBL7066448 | 0.85 | MMP13 (0.62) | USP2HTTSMN1; SMN2MMP1MMP13 | |
| SCHEMBL6962839 | 0.85 | MMP1 (0.74) | MMP1MMP13MMP2CA1CA2 | |
| SCHEMBL7065804 | 0.84 | SMN1; SMN2 (0.60) | USP2HTTSMN1; SMN2MMP1MMP13 | |
| SCHEMBL7251813 | 0.83 | MMP13 (0.55) | MMP1MMP13MMP2CA1CA2 | |
| SCHEMBL5675304 | 0.82 | USP2 (0.60) | USP2HTTSMN1; SMN2MMP1MMP13 | |
| SCHEMBL7410002 | 0.81 | MMP13 (0.48) | USP2MMP1MMP13MMP2MMP9 | |
| SCHEMBL7064268 | 0.81 | HTT (0.60) | USP2HTTSMN1; SMN2MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1616859-B1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU KOGYO CO LTD (JP) | 2013-09-04 | — | — | EP | claimed |
| EP-1616859-A1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU CORPORATION (JP) | 2006-01-18 | — | — | EP | claimed |
| EP-1619189-B1 | N-(3-acyl-2-hydroxyalkyl) cycloalkyl amide derivatives | SEIKAGAKU KOGYO CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-1616859-B1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU KOGYO CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-1616859-B1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU KOGYO CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-1008592-B1 | Cyclic amide derivatives which inhibit cathepsin K | SEIKAGAKU KOGYO CO LTD (JP) | 2006-02-01 | — | — | EP | disclosed |
| EP-1008592-B1 | Cyclic amide derivatives which inhibit cathepsin K | SEIKAGAKU KOGYO CO LTD (JP) | 2006-02-01 | — | — | EP | disclosed |
| EP-1619189-A1 | N-(3-acyl-2-hydroxyalkyl) cycloalkyl amide derivatives | SEIKAGAKU CORPORATION (JP) | 2006-01-25 | — | — | EP | disclosed |
| EP-1616867-A1 | Hydroxycarboxylic acid derivatives | SEIKAGAKU CORPORATION (JP) | 2006-01-18 | — | — | EP | disclosed |
| EP-1616859-A1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU CORPORATION (JP) | 2006-01-18 | — | — | EP | disclosed |
| US-6117870-A | USEFUL AS THERAPEUTIC DRUG OR PREVENTIVE DRUG OF ARTHRITIS AND RHEUMATISM DUE TO INCREASE OF BONE RESORPTION IN ADDITION TO BONE DISEASES SUCH AS OSTEOPOROSIS, HYPERCALCEMIA, AND PAGET'S DISEASE | FUJIREBIO KABUSHIKI KAISHA (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-1008592-A2 | Cyclic amide derivatives which inhibit cathepsin K | Fujirebio Kabushiki Kaisha (JP) | 2000-06-14 | — | — | EP | disclosed |