Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Morphine Glucuronide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.94 |
| ▸ | OPRD1 known ✓ | P41143 | 3/20 | 0.67 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.65 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine Glucuronide SCHEMBL152647 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL17302928 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL13267437 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL12082244 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL612431 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL1743681 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL13268600 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL6754812 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL13245908 | 0.97 | OPRM1 (1.00) | OPRM1MRGPRX2OPRD1OPRK1 | |
| Morphine Glucuronide SCHEMBL5674614 | 0.96 | OPRM1 (0.98) | OPRM1MRGPRX2OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060166900-A1 | Salt of morphine-6-glucuronide | CENES LIMITED (GB) | 2006-07-27 | — | — | US | disclosed |
| EP-1537132-B1 | SALT OF MORPHINE-6-GLUCURONIDE | CENES LTD (GB) | 2006-01-04 | — | — | EP | disclosed |
| EP-1537132-A1 | SALT OF MORPHINE-6-GLUCURONIDE | CeNeS Limited (GB) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004016633-A1 | SALT OF MORPHINE-6-GLUCURONIDE | CENES LIMITED (GB) | 2004-02-26 | — | — | WO | disclosed |