Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 9/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.51 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679166 | 0.88 | CCR2 (0.57) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL5680850 | 0.87 | CCR2 (0.71) | CCR2ABCB11F10 | |
| SCHEMBL6598219 | 0.86 | CCR2 (0.71) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL5680974 | 0.85 | CCR2 (0.62) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL6300548 | 0.83 | CCR2 (0.60) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL5680853 | 0.80 | CCR2 (0.51) | CCR2ABCB11ALOX5AP | |
| SCHEMBL6307749 | 0.79 | CCR2 (0.74) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL5679083 | 0.78 | CCR2 (0.54) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL6300934 | 0.77 | NOD2 (0.66) | CCR2ABCB11NOD2NOD1MAPT | |
| SCHEMBL2428965 | 0.76 | MEN1 (0.46) | CCR2ABCB11NOD2NOD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268423-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | EP | disclosed |
| US-6984657-B1 | Indole derivatives as MCP-1 receptor antagonists | ASTRAZENECA AB (SE) | 2006-01-10 | — | — | US | disclosed |