Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679149 | 0.87 | CCR2 (0.54) | CCR2ABCB11 | |
| SCHEMBL5680850 | 0.86 | CCR2 (0.71) | CCR2ABCB11 | |
| SCHEMBL5682947 | 0.82 | CCR2 (0.57) | CCR2ABCB11 | |
| SCHEMBL5680846 | 0.81 | CCR2 (0.54) | CCR2ABCB11 | |
| SCHEMBL5679342 | 0.80 | CCR2 (0.53) | CCR2ABCB11ALOX5AP | |
| SCHEMBL5681505 | 0.78 | CCR2 (0.53) | CCR2ABCB11 | |
| SCHEMBL5683030 | 0.78 | CCR2 (0.53) | CCR2ABCB11 | |
| SCHEMBL7076795 | 0.77 | CCR2 (0.71) | CCR2ABCB11PPARG | |
| SCHEMBL7072404 | 0.76 | CCR2 (0.67) | CCR2ABCB11 | |
| SCHEMBL5679203 | 0.76 | CCR2 (0.45) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268423-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-03-01 | — | — | EP | claimed |