Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | CHKA | P35790 | 4/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6568492 | 0.95 | TGFBR1 (0.62) | KDM4ECHKATGFBR1ACVR1POLB | |
| SCHEMBL7236258 | 0.86 | TGFBR1 (0.54) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| SCHEMBL5683255 | 0.85 | DRD4 (0.58) | KDM4EPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL4773743 | 0.82 | TGFBR1 (0.53) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| SCHEMBL5572636 | 0.82 | POLB (0.76) | KDM4ECHKAPOLBMEN1ALDH1A1 | |
| SCHEMBL5679814 | 0.81 | KDM4E (0.53) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| Hydrochloric Acid SCHEMBL5572656 | 0.81 | POLB (0.74) | KDM4ECHKAPOLBMEN1ALDH1A1 | |
| SCHEMBL6565335 | 0.81 | KDM4E (0.56) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| SCHEMBL5681800 | 0.79 | DRD4 (0.62) | KDM4EPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL9832407 | 0.79 | KDM4E (0.81) | KDM4EPOLBMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403249-B1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | KOWA CO (JP) | 2006-03-15 | — | — | EP | disclosed |
| EP-1403249-A1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6509329-B1 | Inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation | KOWA CO., LTD. (JP) | 2003-01-21 | — | — | US | disclosed |