Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683737 | 0.96 | TGFBR1 (0.57) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| Hydrochloric Acid SCHEMBL4772448 | 0.83 | TGFBR1 (0.48) | KDM4ETGFBR1ACVR1MEN1KMT2A | |
| SCHEMBL5679807 | 0.81 | KDM4E (0.61) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| SCHEMBL5683255 | 0.80 | DRD4 (0.58) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5679814 | 0.77 | KDM4E (0.53) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| SCHEMBL13800772 | 0.76 | BCHE (0.45) | KDM4ETGFBR1ACVR1MEN1KMT2A | |
| SCHEMBL13800339 | 0.76 | CYP3A4 (0.42) | TGFBR1ACVR1MEN1KMT2AALDH1A1 | |
| SCHEMBL4116108 | 0.76 | CYP11B1 (0.55) | KDM4ETGFBR1ACVR1ALDH1A1ACVR1B | |
| SCHEMBL6568492 | 0.76 | TGFBR1 (0.62) | KDM4ETGFBR1ACVR1POLBMEN1 | |
| SCHEMBL4117618 | 0.76 | FYN (0.45) | KDM4ETGFBR1ACVR1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1403249-A1 | CYCLIC DIAMINE COMPOUNDS BEARING SIX-MEMBERED CYCLIC GROUPS | Kowa Co., Ltd. (JP) | 2004-03-31 | — | — | EP | disclosed |
| US-6509329-B1 | Inhibitory effects on both cell adhesion and cell infiltration and is useful as a medicine for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation | KOWA CO., LTD. (JP) | 2003-01-21 | — | — | US | disclosed |