Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407442 | 0.93 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL6403552 | 0.92 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL5676572 | 0.83 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL6405411 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL5680826 | 0.80 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL8345504 | 0.78 | MAPT (0.62) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL6527991 | 0.77 | ALDH1A1 (0.81) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL31636462 | 0.77 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL31636837 | 0.75 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 | |
| SCHEMBL2554053 | 0.75 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620405-A2 | PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS | Abbott Laboratories (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004099154-A2 | PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2004-11-18 | — | — | WO | disclosed |