Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680923 | 0.92 | ALDH1A1 (0.50) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL5676572 | 0.90 | ALDH1A1 (0.48) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL5680826 | 0.86 | ALDH1A1 (0.60) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL6405411 | 0.86 | ALDH1A1 (0.60) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL31636462 | 0.84 | ALDH1A1 (0.57) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL6527991 | 0.84 | ALDH1A1 (0.81) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL6407442 | 0.83 | ALDH1A1 (0.56) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL8345504 | 0.82 | MAPT (0.62) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL2554053 | 0.82 | ALDH1A1 (0.55) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT | |
| SCHEMBL6403718 | 0.82 | ALDH1A1 (0.55) | ALDH1A1RAB9ASMN1; SMN2TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2005-01-27 | — | — | US | disclosed |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | ALDH1A1 3384/4885RAB9A 3662/4885SMN1; SMN2 395/4885 |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | ALDH1A1 3384/4885RAB9A 3662/4885SMN1; SMN2 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.