Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GPR6 | P46095 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855407 | 0.91 | GPR6 (0.51) | MEN1KMT2AGPR6LMNAL3MBTL1 | |
| SCHEMBL2852214 | 0.84 | GPR6 (0.54) | MEN1KMT2AGPR6KDM4EALDH1A1 | |
| SCHEMBL2855609 | 0.83 | GPR6 (0.53) | MEN1KMT2AGPR6KDM4EALDH1A1 | |
| SCHEMBL4980325 | 0.81 | HSP90AB1 (0.44) | MEN1KMT2AGPR6LMNAHRH3 | |
| SCHEMBL2854088 | 0.81 | GPR6 (0.57) | MEN1KMT2AGPR6KDM4EALDH1A1 | |
| SCHEMBL2858054 | 0.79 | GPR6 (0.53) | MEN1KMT2AGPR6KDM4EALDH1A1 | |
| SCHEMBL5676952 | 0.78 | TP53 (0.62) | MEN1KMT2AGPR6KDM4EALDH1A1 | |
| SCHEMBL2856084 | 0.78 | GPR6 (0.45) | GPR6KDM4ELMNAPOLBMAPT | |
| Hydrochloric Acid SCHEMBL6404593 | 0.78 | TP53 (0.61) | MEN1KMT2AGPR6KDM4EALDH1A1 | |
| SCHEMBL2857536 | 0.78 | TP53 (0.59) | MEN1KMT2AGPR6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620405-A2 | PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS | Abbott Laboratories (US) | 2006-02-01 | — | — | EP | claimed |
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2005-01-27 | — | — | US | claimed |
| WO-2004099154-A2 | PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2004-11-18 | — | — | WO | claimed |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2004-11-04 | — | — | US | claimed |
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2005-01-27 | — | — | US | disclosed |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | ABBOTT LABORATORIES | 2004-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020564-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | MEN1 4304/4885KMT2A 2788/4885GPR6 1393/4885 |
| US-20040220170-A1 | Pyrazole-amides and sulfonamides as sodium channel modulators | SCN3A, KCNN3, TRPV3 | MEN1 4304/4885KMT2A 2788/4885GPR6 1393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.