Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19690700 | 0.78 | ALDH1A1 (0.47) | CTSSMAPTTDP1ALDH1A1CTSK | |
| SCHEMBL6447831 | 0.77 | PPARA (0.39) | CTSSALDH1A1PPARACTSK | |
| SCHEMBL284108 | 0.76 | ALDH1A1 (0.46) | SYKTDP1ALDH1A1PPARAMAPK1 | |
| SCHEMBL9011863 | 0.75 | CTSS (0.46) | CTSSSYKTDP1ALDH1A1PPARA | |
| SCHEMBL9011862 | 0.75 | CTSS (0.46) | CTSSSYKTDP1ALDH1A1PPARA | |
| SCHEMBL5682155 | 0.75 | SYK (0.37) | CTSSSYKMAPTXBP1NPSR1 | |
| SCHEMBL418231 | 0.74 | ALDH1A1 (0.46) | SYKTDP1ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL18482535 | 0.74 | CTSS (0.47) | CTSSSYKMAPTPPARAPOLB | |
| SCHEMBL18970224 | 0.73 | ALDH1A1 (0.49) | CTSSSYKTDP1ALDH1A1CTSK | |
| SCHEMBL9326555 | 0.73 | CTSS (0.44) | CTSSSYKMAPTXBP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934292-B1 | METALLOPROTEINASE INHIBITORS | VERNALIS OXFORD LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| US-6022873-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-02-08 | — | — | US | disclosed |
| EP-0934292-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |