Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679922 | 0.75 | MAPT (0.52) | SYKLMNACTSSL3MBTL1MAPT | |
| SCHEMBL5681996 | 0.75 | CTSS (0.40) | SYKCTSSPOLBGAAL3MBTL1 | |
| SCHEMBL25181806 | 0.71 | LMNA (0.52) | LMNAL3MBTL1ALDH1A1MAPK1MAPT | |
| SCHEMBL5682158 | 0.71 | PSMB5 (0.40) | SYKPOLBGAAPSMB5MAPT | |
| SCHEMBL5677953 | 0.71 | PSMB5 (0.40) | SYKPOLBGAAPSMB5MAPT | |
| SCHEMBL10299300 | 0.70 | LMNA (0.51) | LMNAL3MBTL1ALDH1A1MAPK1TDP1 | |
| SCHEMBL13904629 | 0.70 | ALDH1A1 (0.51) | SYKPOLBL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL9011863 | 0.69 | CTSS (0.46) | SYKCTSSPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL9011862 | 0.69 | CTSS (0.46) | SYKCTSSPOLBL3MBTL1ALDH1A1 | |
| SCHEMBL23303502 | 0.69 | LMNA (0.50) | LMNAL3MBTL1ALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934292-B1 | METALLOPROTEINASE INHIBITORS | VERNALIS OXFORD LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| EP-1066273-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2001-01-10 | — | — | EP | disclosed |
| US-6022873-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-02-08 | — | — | US | disclosed |
| WO-1999048881-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |
| EP-0934292-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |