Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 5/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682142 | 1.00 | CTSB (0.49) | CTSBALDH1A1CTSKCTSSCTSL | |
| SCHEMBL5680064 | 0.87 | CTSK (0.44) | CTSBALDH1A1CTSKCTSSCTSL | |
| SCHEMBL5680067 | 0.87 | CTSK (0.44) | CTSBALDH1A1CTSKCTSSCTSL | |
| SCHEMBL9507442 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SLC15A1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL16681232 | 0.83 | CTSB (0.61) | CTSBALDH1A1CTSKCTSSCTSL | |
| SCHEMBL7279716 | 0.83 | ALDH1A1 (0.55) | ALDH1A1CTSKSLC15A1MAPK1L3MBTL1 | |
| SCHEMBL11707070 | 0.83 | CTSB (0.61) | CTSBALDH1A1CTSKCTSSCTSL | |
| SCHEMBL5678072 | 0.83 | CACNA1B (0.44) | CTSKCTSSCTSL | |
| SCHEMBL5677963 | 0.83 | CACNA1B (0.44) | CTSKCTSSCTSL | |
| Hydrochloric Acid SCHEMBL11707065 | 0.81 | CTSB (0.60) | CTSBALDH1A1CTSKCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934292-B1 | METALLOPROTEINASE INHIBITORS | VERNALIS OXFORD LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| EP-1066273-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2001-01-10 | — | — | EP | disclosed |
| US-6022873-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 2000-02-08 | — | — | US | disclosed |
| WO-1999048881-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |
| EP-0934292-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017655-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |