Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metaproterenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 16/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.96 |
| ▸ | MEN1 | O00255 | 1/20 | 0.81 |
| ▸ | LMNA | P02545 | 1/20 | 0.81 |
| ▸ | APEX1 | P27695 | 1/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.62 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metaproterenol SCHEMBL4271 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL3694829 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL4451598 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL4270 | 0.98 | ADRB2 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL6141868 | 0.96 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL5682997 | 0.96 | ADRB2 (0.96) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL15392269 | 0.90 | ADRB2 (0.83) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL41816 | 0.90 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL9614523 | 0.90 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 | |
| Metaproterenol SCHEMBL3049439 | 0.90 | MEN1 (1.00) | ADRB2TSHRHIF1AADRA1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107735401-B | Substituted dihydropyrrolopyrazole derivatives | 宇部兴产株式会社 | 2021-08-31 | — | — | CN | disclosed |