SCHEMBL5683134

SCHEMBL5683134

O=C(Cl)c1cc(Cl)nc(Cl)n1

nearest known ligand 0.50

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.50
S1PR2 O95136 1/20 0.39
KMO O15229 1/20 0.36
SIRT6 Q8N6T7 1/20 0.33
ATF1 P18846 1/20 0.33
NFKB1 P19838 1/20 0.33
GPR35 Q9HC97 1/20 0.32
ALDH1A1 P00352 2/20 0.31
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3055010 0.83 LMNA (0.47) LMNAKMOGPR35ALDH1A1MAPK1
SCHEMBL986362 0.82 KMO (0.51) LMNAS1PR2KMOGPR35ALDH1A1
Hydrochloric Acid SCHEMBL6525079 0.80 KMO (0.50) LMNAS1PR2KMOGPR35ALDH1A1
SCHEMBL3659442 0.80 LMNA (0.79) LMNAS1PR2KMOSIRT6
SCHEMBL113130 0.80 LMNA (0.48) LMNAS1PR2KMOATF1NFKB1
SCHEMBL985142 0.78 KMO (0.39) LMNAS1PR2KMOSIRT6GPR35
SCHEMBL7233011 0.77 S1PR2 (0.39) LMNAS1PR2KMOSIRT6GPR35
SCHEMBL9912240 0.77 LMNA (0.45) LMNAS1PR2KMOATF1NFKB1
Bicarbonate SCHEMBL10635309 0.75 LMNA (0.46) LMNAS1PR2KMOATF1NFKB1
SCHEMBL31373554 0.75 LMNA (0.48) LMNAS1PR2ATF1NFKB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119875230-A Plastic particle based on polyolefin and production process thereof 广州广化塑料管道有限公司 2025-04-25 CN claimed
US-20250382283-A1 COMPOUNDS AND THEIR USES AS CD38 INHIBITORS NANJING IMMUNOPHAGE BIOTECH CO LTD (CN) 2025-12-18 US disclosed
CN-119875230-A Plastic particle based on polyolefin and production process thereof 广州广化塑料管道有限公司 2025-04-25 CN disclosed
WO-2024233665-A1 COMPOUNDS AND THEIR USE AGAINST CANCER TANGO THERAPEUTICS, INC. (US) 2024-11-14 WO disclosed
CN-113166177-B Boron-containing PDE4 inhibitors 辉瑞公司 2024-09-03 CN disclosed
US-20240254113-A1 COMPOUNDS AND THEIR USES AS CD38 INHIBITORS Nanjing Immunophage Biotech Co., Ltd. (CN) 2024-08-01 US disclosed
CN-117715897-A Compounds and their use as CD38 inhibitors 南京艾美斐生物医药科技有限公司 2024-03-15 CN disclosed
EP-3861001-B1 BORON CONTAINING PDE4 INHIBITORS PFIZER (US) 2023-12-13 EP disclosed
EP-3861001-B1 BORON CONTAINING PDE4 INHIBITORS PFIZER (US) 2023-12-13 EP disclosed
US-11834447-B2 Indole derivatives and use thereof PURDUE PHARMA L.P. (US) 2023-12-05 US disclosed
US-4039523-A YELLOW CIBA-GEIGY AG (CH) 1977-08-02 US disclosed
US-4017477-A 3-Halogeno-6-hydroxy-pyridone-(2) azo dyestuffs CIBA-GEIGY AG (CH) 1977-04-12 US disclosed
US-4015000-A 6-Acylamino-penam-3-carboxylic and 7-acylamino-3-cephem-4-carboxylic acids CIBA-GEIGY CORPORATION (US) 1977-03-29 US disclosed
US-4001203-A Heavy metal complexes of azo dyestuffs containing a heterocyclic diazo component and the residue of 5-halogeno-2,3-dihydrozypyridine as coupling component CIBA-GEIGY AG (CH) 1977-01-04 US disclosed
US-4001205-A WATER-SOLUBLE, FIBER-REACTIVE PHENYLAZODIHYDROXY, METHYL, CYANOPYRIDINE DYESTUFFS CIBA-GEIGY AG (CH) 1977-01-04 US disclosed
US-3989692-A PHTHALOCYANINE DYES, WOOL, SILK, POLYAMIDES, CELLULOSE BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed
US-3988310-A FIBER-REACTIVE DYES; CELLULOSE BAYER AKTIENGESELLSCHAFT (DT) 1976-10-26 US disclosed
US-3971738-A Heavy metal complexes of azo compounds containing a halogeno-2,3-dihydroxy pyridine coupling component CIBA-GEIGY AG (CH) 1976-07-27 US disclosed
US-3957751-A WATER-SOLUBLE REACTIVE DYESTUFFS OF THE MONOAZO SERIES CONTAINING AN ACTIVE METHYLENE COUPLING COMPONENT HOECHST AKTIENGESELLSCHAFT (DT) 1976-05-18 US disclosed
US-3956263-A 4-Methyl-2,6-dihydroxy-3-cyanopyridine containing dyestuffs CIBA-GEIGY AG (CH) 1976-05-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11834447-B2 Indole derivatives and use thereof TRPC4, TRPV4, TRPV1 LMNA 2526/4885S1PR2 569/4885KMO 425/4885
US-20240254113-A1 COMPOUNDS AND THEIR USES AS CD38 INHIBITORS CD38, CD22, BCL6B LMNA 518/4885S1PR2 651/4885KMO 3914/4885
US-20250382283-A1 COMPOUNDS AND THEIR USES AS CD38 INHIBITORS CD38, FCGRT, CD22 LMNA 1234/4885S1PR2 438/4885KMO 2955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.