Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HMGCR | P04035 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19792815 | 0.90 | GABBR2 (0.41) | TSHRPOLBHMGCRMEN1CYP1A2 | |
| SCHEMBL8811318 | 0.89 | MEN1 (0.40) | TSHRPOLBHMGCRMEN1CYP1A2 | |
| SCHEMBL8602788 | 0.85 | CPB2 (0.39) | TSHRPOLBHMGCRMEN1CYP1A2 | |
| SCHEMBL19468552 | 0.81 | TSHR (0.43) | TSHRPOLBHMGCRTP53TDP1 | |
| SCHEMBL19792824 | 0.79 | CYP1A2 (0.41) | TSHRPOLBHMGCRMEN1CYP1A2 | |
| SCHEMBL27762774 | 0.78 | POLB (0.38) | TSHRPOLBMEN1CYP1A2KMT2A | |
| SCHEMBL12440450 | 0.77 | TSHR (0.40) | TSHRPOLBHMGCRTP53TDP1 | |
| SCHEMBL13334729 | 0.77 | FDPS (0.52) | TSHRPOLBHMGCRTP53TDP1 | |
| SCHEMBL9063345 | 0.77 | PPARD (0.46) | TSHRPOLBHMGCRTP53TDP1 | |
| SCHEMBL5679623 | 0.77 | TP53 (0.42) | TSHRPOLBHMGCRTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101215297-A | Statin-diphosphonic acid conjugates, preparation method and application thereof | UNIV HUNAN NORMAL (CN) | 2008-07-09 | — | — | CN | claimed |
| US-10280188-B2 | Fluorine-containing bisphosphonic acid derivative and use thereof | NAGASAKI UNIVERSITY (JP) | 2019-05-07 | — | — | US | disclosed |
| US-20180022769-A1 | NOVEL FLUORINE-CONTAINING BISPHOSPHONIC ACID DERIVATIVE AND USE THEREOF | NAGASAKI UNIVERSITY (JP) | 2018-01-25 | — | — | US | disclosed |
| CN-101215297-B | Statin-diphosphonic acid conjugates, preparation method and application thereof | UNIV HUNAN NORMAL | 2011-09-14 | — | — | CN | disclosed |
| CN-101215297-A | Statin-diphosphonic acid conjugates, preparation method and application thereof | UNIV HUNAN NORMAL (CN) | 2008-07-09 | — | — | CN | disclosed |
| EP-0831869-B1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-0831869-A4 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS IN (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5880111-A | CHEMOTHERAPWUTIC AGENTS; TREATING PERIODONTAL DISEASE AND URINARY TRACT INFECTIONS | FARCASIU DAN (US) | 1999-03-09 | — | — | US | disclosed |
| EP-0831869-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | Elizanor Biopharmaceuticals, Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040190-A1 | DIPHOSPHONATE DERIVATIVES OF THERAPEUTIC AGENTS | ELIZANOR BIOPHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0549645-B1 | NEW 17- -OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1994-08-31 | — | — | EP | disclosed |
| EP-0549645-A1 | NEW 17- -OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM. | BOEHRINGER MANNHEIM GMBH (DE) | 1993-07-07 | — | — | EP | disclosed |
| WO-1992005187-A1 | NEW 17-β-OESTRADIOL DERIVATIVES, A METHOD OF PREPARING THEM, AND DRUGS CONTAINING THEM | BOEHRINGER MANNHEIM GMBH (DE) | 1992-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280188-B2 | Fluorine-containing bisphosphonic acid derivative and use thereof | CD4, CD22, CD69 | TSHR 263/4885POLB 1143/4885HMGCR 4716/4885 |
| US-20180022769-A1 | NOVEL FLUORINE-CONTAINING BISPHOSPHONIC ACID DERIVATIVE AND USE THEREOF | CD4, CD22, CD69 | TSHR 213/4885POLB 1142/4885HMGCR 4704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.